KEGG   DRUG: Dapagliflozin
Entry
D08897                      Drug                                   
Name
Dapagliflozin (JAN/USAN/INN);
Forxiga (TN)
Formula
C21H25ClO6
Exact mass
408.134
Mol weight
408.8726
Structure
Simcomp
Class
Antidiabetic agent
 DG02044  Hypoglycemic agent
  DG01794  SGLT2 inhibitor
Metabolizing enzyme substrate
 DG02924  UGT substrate
  DG03188  UGT1A9 substrate
Remark
Same as: C22193
ATC code: A10BK01
Chemical structure group: DG00122
Product (DG00122): D09763<JP/US>
Product (mixture): D10586<US> D10826<US>
Efficacy
Antidiabetic, SGLT-2 inhibitor
Comment
Phlorizin derivative
Treatment of type 1 or type 2 diabetes, or any condition causing hyperglycemia
Target
SLC5A2 (SGLT2) [HSA:6524] [KO:K14382]
Metabolism
Enzyme: UGT1A9 [HSA:54600]
Interaction
Structure map
map07051  Antidiabetics
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A10 DRUGS USED IN DIABETES
   A10B BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS
    A10BK Sodium-glucose co-transporter 2 (SGLT2) inhibitors
     A10BK01 Dapagliflozin
      D08897  Dapagliflozin (JAN/USAN/INN)
Drug groups [BR:br08330]
 Antidiabetic agent
  DG02044  Hypoglycemic agent
   DG01794  SGLT2 inhibitor
    DG00122  Dapagliflozin
     D08897  Dapagliflozin
 Metabolizing enzyme substrate
  DG02924  UGT substrate
   DG03188  UGT1A9 substrate
    DG00122  Dapagliflozin
     D08897  Dapagliflozin
Target-based classification of drugs [BR:br08310]
 Transporters
  Solute carrier family
   SLC5
    SLC5A2 (SGLT2)
     D08897  Dapagliflozin (JAN/USAN/INN)
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D08897
Drug groups [BR:br08330]
 Antidiabetic agent
  DG02044  Hypoglycemic agent
   DG01794  SGLT2 inhibitor
    DG00122  Dapagliflozin
 Metabolizing enzyme substrate
  DG02924  UGT substrate
   DG03188  UGT1A9 substrate
    DG00122  Dapagliflozin
Other DBs
CAS: 461432-26-8
PubChem: 96025580
ChEBI: 85078
PDB-CCD: LE6[PDBj]
LigandBox: D08897
KCF data

ATOM        28
            1   C8y C    24.2958  -19.6721
            2   C8x C    24.2958  -21.0723
            3   C8x C    25.5083  -21.7724
            4   C8y C    26.7210  -21.0723
            5   C8y C    26.7210  -19.6721
            6   C8x C    25.5083  -18.9720
            7   C1b C    27.9523  -18.9610
            8   C8y C    29.1576  -19.6568
            9   C8x C    29.1580  -21.0719
            10  C8x C    30.3708  -21.7717
            11  C8y C    31.5833  -21.0712
            12  C8x C    31.5828  -19.6560
            13  C8x C    30.3700  -18.9563
            14  X   Cl   27.9523  -21.7834
            15  O2a O    32.7916  -21.7684
            16  C1b C    33.9837  -21.0796
            17  C1a C    35.1734  -21.7660
            18  C1y C    23.0832  -18.9720
            19  O2x O    23.0832  -17.5720
            20  C1y C    21.8706  -16.8719
            21  C1y C    20.6580  -17.5720
            22  C1y C    20.6580  -18.9720
            23  C1y C    21.8706  -19.6721
            24  O1a O    21.8706  -21.0721
            25  O1a O    19.4433  -16.8707
            26  O1a O    19.4433  -19.6733
            27  C1b C    21.8706  -15.4718
            28  O1a O    23.0661  -14.7814
BOND        30
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     5   7 1
            8     7   8 1
            9     8   9 2
            10    9  10 1
            11   10  11 2
            12   11  12 1
            13   12  13 2
            14    8  13 1
            15    4  14 1
            16   11  15 1
            17   15  16 1
            18   16  17 1
            19   18   1 1 #Up
            20   18  19 1
            21   19  20 1
            22   20  21 1
            23   21  22 1
            24   22  23 1
            25   18  23 1
            26   23  24 1 #Down
            27   21  25 1 #Down
            28   22  26 1 #Up
            29   20  27 1 #Up
            30   27  28 1

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