| Entry |
|
|---|
| Name |
Dapagliflozin (JAN/USAN/INN);
Forxiga (TN) |
|---|
| Formula |
C21H25ClO6
|
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| Exact mass |
408.134
|
|---|
| Mol weight |
408.8726
|
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| Structure |
|
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| Simcomp |
|
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| Class |
Antidiabetic agent
DG02044 Hypoglycemic agent
DG01794 SGLT2 inhibitor
Metabolizing enzyme substrate
DG02924 UGT substrate
DG03188 UGT1A9 substrate
|
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| Remark |
| Product (DG00122): | D09763<JP/US> |
| Product (mixture): | D10586<US> D10826<US> |
|
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| Efficacy |
Antidiabetic, SGLT-2 inhibitor |
|---|
| Comment |
Phlorizin derivative
Treatment of type 1 or type 2 diabetes, or any condition causing hyperglycemia
|
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| Target |
|
|---|
| Metabolism |
Enzyme: UGT1A9 [HSA: 54600]
|
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| Interaction |
|
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| Structure map |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
A ALIMENTARY TRACT AND METABOLISM
A10 DRUGS USED IN DIABETES
A10B BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS
A10BK Sodium-glucose co-transporter 2 (SGLT2) inhibitors
A10BK01 Dapagliflozin
D08897 Dapagliflozin (JAN/USAN/INN)
Drug groups [BR:br08330]
Antidiabetic agent
DG02044 Hypoglycemic agent
DG01794 SGLT2 inhibitor
DG00122 Dapagliflozin
D08897 Dapagliflozin
Metabolizing enzyme substrate
DG02924 UGT substrate
DG03188 UGT1A9 substrate
DG00122 Dapagliflozin
D08897 Dapagliflozin
Target-based classification of drugs [BR:br08310]
Transporters
Solute carrier family
SLC5
SLC5A2 (SGLT2)
D08897 Dapagliflozin (JAN/USAN/INN)
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D08897
Drug groups [BR:br08330]
Antidiabetic agent
DG02044 Hypoglycemic agent
DG01794 SGLT2 inhibitor
DG00122 Dapagliflozin
Metabolizing enzyme substrate
DG02924 UGT substrate
DG03188 UGT1A9 substrate
DG00122 Dapagliflozin
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| Other DBs |
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| KCF data |
ATOM 28
1 C8y C 24.2958 -19.6721
2 C8x C 24.2958 -21.0723
3 C8x C 25.5083 -21.7724
4 C8y C 26.7210 -21.0723
5 C8y C 26.7210 -19.6721
6 C8x C 25.5083 -18.9720
7 C1b C 27.9523 -18.9610
8 C8y C 29.1576 -19.6568
9 C8x C 29.1580 -21.0719
10 C8x C 30.3708 -21.7717
11 C8y C 31.5833 -21.0712
12 C8x C 31.5828 -19.6560
13 C8x C 30.3700 -18.9563
14 X Cl 27.9523 -21.7834
15 O2a O 32.7916 -21.7684
16 C1b C 33.9837 -21.0796
17 C1a C 35.1734 -21.7660
18 C1y C 23.0832 -18.9720
19 O2x O 23.0832 -17.5720
20 C1y C 21.8706 -16.8719
21 C1y C 20.6580 -17.5720
22 C1y C 20.6580 -18.9720
23 C1y C 21.8706 -19.6721
24 O1a O 21.8706 -21.0721
25 O1a O 19.4433 -16.8707
26 O1a O 19.4433 -19.6733
27 C1b C 21.8706 -15.4718
28 O1a O 23.0661 -14.7814
BOND 30
1 1 2 2
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 2
6 1 6 1
7 5 7 1
8 7 8 1
9 8 9 2
10 9 10 1
11 10 11 2
12 11 12 1
13 12 13 2
14 8 13 1
15 4 14 1
16 11 15 1
17 15 16 1
18 16 17 1
19 18 1 1 #Up
20 18 19 1
21 19 20 1
22 20 21 1
23 21 22 1
24 22 23 1
25 18 23 1
26 23 24 1 #Down
27 21 25 1 #Down
28 22 26 1 #Up
29 20 27 1 #Up
30 27 28 1
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